Association of 8p22-23-rs2254546 Genotypes with Coronary Artery Status and Resistance to Intravenous Immunoglobulin in Iranian Children with Kawasaki Disease

Background: Kawasaki disease (KD) is a frequent cause of acquired heart in infants and young children, which may be triggered by infectious agents, with the highest incidence Asian countries. Several genotypes are identified as susceptibility genes for KD, but none known Iranian population. Objectives: Due to racial differences frequency significance genes, we aimed investigate 8p22-23-rs2254546 sample children their association aneurysm resistance treatment. Methods: In this prospective cross-sectional study, 100 KD group were compared matched unrelated healthy no history or immune-related disease. The control subjects ethnically recruited from same hospital at time routine physical examination. analyzed using polymerase chain reaction (PCR) direct sequencing techniques, three (GA, AA, GG) was reported. Finally, IVIG reported, associations tested SPSS software. Results: Of patients mean age 1.9 ± 1.7 (0.1 - 10.2) years, 57% boys 43% girls. them, 62% had GG, 30% GA, 8% AA genotypes. Besides, 21% studied resistant IVIG, 19% aneurysm, not associated GG GA (P = 0.29 0.88, respectively). Conclusions: majority shown have genetic susceptibility, shows importance genotype children. However, risk aneurysm.